principal scientist - r&d t-cell immunotherapy.
+ covina , california
+ posted 1 day ago
+ $130,000 - $150,000 per year
+ postgraduate degree
+ category life, physical, and social science occupations
Make a splash at this fast-paced and rapidly growing biotech start up! Here, you will contribute your talents in a purposeful way that impacts the lives of patients around the world. You will be supporting the development and manufacturing of cell and gene immunotherapies for the treatment of cancer and rare diseases, in a state of the art facility.
The R & D team is seeking a motivated, collaborative, and highly skilled Senior Scientist/Principal Scientist with passion for developing T cell-based immunotherapies to treat hematologic malignancies and solid tumors. Candidate is expected to lead various aspects of preclinical development and validation of novel T cell / antibody therapeutics. He / She will work closely with our internal colleagues and external collaborators to efficiently progress early-stage cell therapy products through to IND filing. This position will report directly to the Director of Research & Development, immunotherapy and will play a critical role in development and translation of novel CAR-T therapies to the clinic.
The successful candidate has extensive experience in a combination of skills including, genetic manipulation of T cells and tumor cells using viral/nonviral methods, VCN determination using qPCR/ddPCR, T/NK cell isolation, optimization of culture conditions, development, and optimization of a variety of assays (molecular, cell based, biochemical, immunological) for preclinical validation of cell therapy products. Candidate is expected to demonstrate in-depth understanding of current research and technological developments in adaptive T cell immunotherapy. Prior experience in managing 3-4 direct reports at PhD level scientists is required.
We seek passionate, self-driven, and dedicated individual who takes initiative, contribute to innovative ideas, independently design /execute experiments, and perform critical data analysis.
An ideal candidate is well organized, pays attention to details, works well in team setting, shows sense of urgency and responsibility to complete tasks meticulously on time. Additionally, 3-5 years of experience in managing research personnel/projects required. He/she will independently design and execute experiments, mentor Ph. D level scientists, collaborate with other cross functional teams to support research projects under the supervision of R & D Director. Passion for excellence and innovation to improvise cell therapy is critical.
Hours: 8:30 AM - 5:00 PM
location: Covina, California
job type: Permanent
salary: $130,000 - 150,000 per year
work hours: 9 to 5
+ Lead planning, design, and execution of experiments related of development and characterization of cellular immunotherapy products in coordination with R & D director.
+ Analyze, and report complex data to cross functional teams in a clear and concise manner
+ Mentor and train scientific staff on technical skills required to effectively perform experiments and to facilitate progression of projects (Multicolor flow cytometry, multiplex cytokine assays, Image cytometry)
+ Manage multiple research projects simultaneously with the R & D team and collaborate with other departments (Process Science, Analytical Science, Quality, Manufacture) as necessary.
+ Contribute to various preclinical projects within R& D and those required by clients through in-depth scientific knowledge and demonstrated experience in analytical methods used in cellular immunotherapy field
+ Manage the work of multiple late preclinical stage clients effectively to drive projects to completion
+ Work closely with our internal colleagues to efficiently progress early-stage CAR-T products to IND filing
+ Collaborate with Process science team to scale up CAR-T products
+ Provide support for drafting client reports, patents, SOPs, and peer-reviewed scientific publications
+ Provide scientific and technical support to direct reports and other team members (Scientists and RA)
+ Maintain precise laboratory notebooks, electronic records following high standards of data quality and integrity.
+ Proactively identify and supervise solutions to challenges, risks, and changes that could lead to project delays or cost changes
+ Prepare scientific/technical reports, summaries, protocols, etc, and present them to internal and external stakeholders.
+ Constantly improvise research strategies and adopt technologies to stay upfront in the field of immunotherapy
+ Ph. D in the field of Immunology, Cell biology, Virology or Cancer biology or related life science discipline with 5+ years (Senior Scientist) or Master's degree with 7 + years relevant research experience in Immunology/Cancer biology
+ Extensive experience in working with different mammalian cells lines and primary human cells (adherent tumor cells, PBMCs, primary T, NK, and macrophages)
+ Experience in engineering T or other immune and tumor cell types using retro/lentiviral/nonviral platforms and downstream functional assays
+ Experience with transfection, electroporation, and transduction methods
+ Highly skilled in multi-parameter flow cytometric analysis of immune cells from blood products. Must be able to independently design panels, acquire, analyze, and interpret data
+ Demonstrated experience in a variety of molecular, cellular, biochemical, and immunological techniques (molecular cloning, transfections, transductions, western blotting, immunoprecipitation, qPCR/ddPCR, flow cytometry, ELISA, MSD, multiplex cytokine assays)
+ Experience in lentiviral packaging and characterization using qPCR, flow cytometry and ELISA
+ Experience in T cell co-culture functional assays to measure T cell activation, cytokine release (ELISA or intracellular staining by FACs), proliferation (CFSE).
+ Prior expertise in different cytotoxicity methods commonly used in T cell immunotherapy (Luminescence, release assays, image cytometry, and impedance assays)
+ Prior experience in engineering tumor cells with shRNA, CRISPR or other genetic elements
+ Direct experience working on projects in the area of adaptive T cell immunotherapy is highly desired.
+ Prior research experience in antibody therapies, bispecific antibodies, and cellular therapies preferred
+ Familiarity with FDA regulation of biologics and cell therapy products, IND-filing, GLP/GMP process is a plus.
+ A strong academic or industry research experience in immunotherapy evidenced by high caliber publications in peer-reviewed journals is desirable
skills: Cell Biology, PCR, Data Analysis, GLP (Good Laboratory Practice), Flow Cytometry
Equal Opportunity Employer: Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.
At Randstad, we welcome people of all abilities and want to ensure that our hiring and interview process meets the needs of all applicants. If you require a reasonable accommodation to make your application or interview experience a great one, please contact [Click Here to Email Your Resumé].
Pay offered to a successful candidate will be based on several factors including the candidate's education, work experience, work location, specific job duties, certifications, etc. In addition, Randstad offers a comprehensive benefits package, including health, an incentive and recognition program, and 401K contribution (all benefits are based on eligibility).
Qualified applicants in San Francisco with criminal histories will be considered for employment in accordance with the San Francisco Fair Chance Ordinance.
We will consider for employment all qualified Applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance.
For certain assignments, Covid-19 vaccination and/or testing may be required by Randstad's client or applicable federal mandate, subject to approved medical or religious accommodations. Carefully review the job posting for details on vaccine/testing requirements or ask your Randstad representative for more information.
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